Kieran Culkin and Zoe Saldaña among the first winners at the Golden Globes

American actresses Demi Moore and Sebastian Stan are among the biggest winners at the Golden Globe Awards, which took place in Los Angeles.

Moore was nominated for best actor in a musical or comedy for his performance in the horror film The Substance, which revived his career and earned him an Oscar nomination.

“I’m in shock right now… I didn’t expect that,” Moore said as he took the stage. “I’ve been doing this for a long time, 45 years, and this is the first time I’ve won anything as an actor.”

Other winners include Kieran Culkin and Zoe Saldaña and the TV series Baby Reindeer and Shōgun.

Blockbuster Wicked missed out on major awards, but won the box office and the cinematic achievement award, which was presented last year.

In his acceptance speech, Moore said: “Thirty years ago, I once had a producer tell me I was a popcorn actor, and at the time I said so. [awards] it was not something that I was allowed to have, that I could make successful films and make a lot of money but they were not approved.

“And I bought in and believed that. That hurt me over time to the point that a few years ago I thought maybe this is it, maybe I was perfect, I was doing what I was supposed to do.

“And when I was at the bottom, I had this app, out of the box, a bonkers script came across my desktop, called Substance, and the whole world told me I wasn’t done yet.”

Stan was nominated for Best Actor in a Musical or Comedy for A Different Man, which sees him play a character who changes his appearance dramatically.

“Our ignorance and discomfort about disability and disability must end now, we must correct it and continue to express ourselves, and our children, to encourage acceptance.”

Culkin won best supporting actress for her performance in A Real Pain, about two cousins ​​traveling through Poland to remember their grandmother.

“The first recognition I got as an actor was a Golden Globe nomination when I was a kid. Now, it’s like the best night my wife and I have ever had,” he joked.

Saldaña, who won best supporting actress for her role in the Spanish-language musical Emilia Pérez, said: “My heart is full of gratitude.”

“I am very happy to join the other nominees at this time,” he continued. “I know it’s a competition but all I’ve seen is that we’re celebrating each other and it’s just beautiful.”

The film also won best film in a foreign language where director Jacques Audiard took the stage with a French translator to accept the award.

“In these troubled times, I hope that Emilia Perez will be a light,” he said. “I hope to give a comforting hug to those who are worried… I urge them to keep their heads up and hope for a few better days.”

There was a surprise but welcome winner in the animated feature category, which saw box office juggernauts The Wild Robot and Inside Out 2 beaten by Flow, a film about animals who must work together to survive after a flood.

“This film was made by a very small, small, but passionate team, in a place where there is no big film industry, so it’s the first time a Latvian film has been here so this is big for us,” said director Gints Zilbalodis.

Elsewhere, Baby Reindeer was named the best limited TV series, which was accepted by its writer and creator Richard Gadd.

“Many people ask me why the black program was as successful as it was,” he said. “And I think that in many ways, people were crying out for something that speaks to the painful inconsistency of being human.

“For a long time there has been this belief in television that stories that are too dark and complex will not sell and no one will watch them, so I hope that Baby Reindeer has put an end to that idea, because right now, when the world is in the situation it is in and people are struggling, we need stories that talk about a complex and difficult situation of our times.”

British actress Jessica Gunning has been named best TV supporting actress for her portrayal of a security guard in the hit Netflix series.

In his acceptance speech, Gunning shared an anecdote about getting a hamster for Christmas as a child, and thinking he couldn’t believe it was happening to him. He said this speech has become “the song of my life this year”.

“Thanks to Richard Gadd, Baby Reindeer has changed my life in ways I can’t even explain. I can’t believe this is happening to me,” she repeated, “and I know I wouldn’t be eight years old. Well, you’re going to be crazy.”

Irish actor Colin Farrell won his third Golden Globe, for playing the Batman villain Penguin in the HBO series of the same name.

On stage, he joked that he has “no one to thank” and “he did it all by himself”.

Recalling the three hours it took him to put on prosthetics to make him a villain in his latest film, he said: “In the morning, I drank black coffee, listened to 80s music, and became a canvas for that group’s creativity. “

Farrell also said: “Thanks for hiring me. And yes, I think it’s prosthetics from here on out.”

The Golden Globes mark the first major event of the film awards season, which culminates with the Oscars on March 2.

A win at the Globes could help boost the film’s profile at a crucial time, when Bafta and Oscar voters are preparing to fill out their nomination ballots.